|
Chronic Lymphocytic Leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The nondeleted allele of the CAR and EST70/Leu1 genes was expressed in B-CLL specimens, including those with monoallelic loss, whereas no expression of 1B4/Leu2 was detectable in B-CLL, regardless of the 13q14 status.
|
11264177 |
2001 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
The nondeleted allele of the CAR and EST70/Leu1 genes was expressed in B-CLL specimens, including those with monoallelic loss, whereas no expression of 1B4/Leu2 was detectable in B-CLL, regardless of the 13q14 status.
|
11264177 |
2001 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The CD5 gene expression was in all cases identical to that of T-cell malignancies.
|
1690580 |
1990 |
|
Malignant Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
We determined that the transcription of the CD5 gene in T cell malignancies, CLL, SLL and a selected group of EBV transformed lines was identical.
|
1721931 |
1991 |
|
leukemia
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
CTLA-4 overexpression in CD19+/CD5+ cells correlates with the level of cell cycle regulators and disease progression in B-CLL patients.
|
15549146 |
2005 |
|
B-Cell Lymphomas
|
0.020 |
AlteredExpression
|
group |
LHGDN |
De novo CD5+ diffuse large B-cell lymphoma: results of a detailed clinicopathological review in 120 patients.
|
18556402 |
2008 |
|
Lymphocytosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Tumors associated with peripheral lymphocytosis more commonly expressed the Leu-1 antigen (P less than 0.01) and IgD (P less than 0.01) and less frequently were stained by BA-2 (P less than 0.05) and OKT9 (P less than 0.05).
|
3322023 |
1987 |
|
Lymphoproliferative Disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Despite the low incidence of microsatellite instability (MSI) in lymphoid malignant neoplasms, it has been reported that the CD5 promoter MSI was relatively frequent among B-cell chronic lymphoproliferative disorders.
|
15981803 |
2005 |
|
Lymphoma, T-Cell, Cutaneous
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Subtypes of cutaneous T-cell lymphoma defined by expression of leu-1 and Ia.
|
7042004 |
1982 |
|
Pleural Effusion, Malignant
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Most of the cells taken from the malignant pleural effusion expressed T cell-associated antigens such as Leu-1 and OKT 8.
|
3097073 |
1986 |
|
Thymic Squamous Cell Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The primary carcinoma showing thymus-like elements of the thyroid frequently expresses KIT and CD5 proteins; similar to thymic squamous cell carcinoma, the overexpression of KIT does not necessarily indicate a gene mutation in this tumor.
|
21835435 |
2012 |
|
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lack of expression of sCD5 on T-ALL blasts was correlated closely with predominant transcription of exon E1B and significant loss of exon E1A of the CD5 gene, which is associated with surface expression of CD5 on lymphocytes.
|
28752543 |
2017 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples.
|
15981803 |
2005 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.050 |
PosttranslationalModification
|
disease |
BEFREE |
We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples.
|
15981803 |
2005 |
|
Mantle cell lymphoma
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
We studied the presence of MSI in the CD5 promoter in 134 cases of B-cell chronic lymphocytic leukemia (B-CLL) and 47 of mantle cell lymphoma (MCL) by comparing the pattern of microsatellite repeats on autologous germline and tumor DNA samples.
|
15981803 |
2005 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
|
9395242 |
1997 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
|
12094250 |
2002 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Recently, we found that the G6 CRI also is expressed frequently by neoplastic CD5 (Leu1) B cells from patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma.
|
2503826 |
1989 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The leukemic cells from 95% of patients with B cell chronic lymphocytic leukemia (CLL) coexpress B cell differentiation antigens and the pan-T lymphocyte surface antigen CD5 (Leu 1).
|
1689356 |
1990 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Flow cytometric analysis of forward- and right-angle light scatters demonstrated the presence of two populations of cells, one lymphoid, bearing predominantly lambda light chain surface immunoglobulin and showing phenotypic characteristics of B cell chronic lymphocytic leukemia (HLA-DR-positive, BL-1-positive, BL-2-positive, BL-7-positive, Leu-1-positive, Leu-10-positive, BL-5-negative, BL-6-negative, and OKM1-negative), and another granulocytic population expressing phenotypic features compatible with myeloid lineage (HLA-DR-negative, Leu-1-negative, BL-1-negative, BL-2-negative, BL-7-negative, Leu-10-negative, BL-5-positive, BL-6-negative, OKM1-positive, and surface immunoglobulin-negative).
|
3456199 |
1986 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
CTD_human |
Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis.
|
18006695 |
2008 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Malignant CD5 B cells obtained from patients with chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) were analyzed for immunoglobulin variable gene usage, CD5 gene expression and autoantibody production.
|
1721931 |
1991 |
|
Chronic Lymphocytic Leukemia
|
0.400 |
Biomarker
|
disease |
LHGDN |
Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and analysis of CD5-regulated genes in a B cell line suggest a role for CD5 in malignant phenotype.
|
17878328 |
2007 |
|
Rheumatoid Arthritis
|
0.300 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
|
B-CELL MALIGNANCY, LOW-GRADE
|
0.050 |
Biomarker
|
disease |
BEFREE |
Deletion analysis of chromosome 13q14.3 and characterisation of an alternative splice form of LEU1 in B cell chronic lymphocytic leukemia.
|
12094250 |
2002 |